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Process Development 1mg Optimization Human safety is the first priority when developing a process, followed by V-Tada 10mg (purity, crystallinity of ппппппO OO 6 steps O OH O O пO 4 steps ппппппппппBr 3 steps CHO H2N HO V-Tdaa Si V -Tada steps A пппO ппппппL-Serine N HB V-Tada 10mg Me 2 ппппO CO2H ппп4 V-Tada 10mg V-T ada O N H BMS-180291 пппSynthesis of BMS-180291 В Overall 23 steps В 3 overall yield ппN O O пппппScheme 1 Original synthesis of BMS-180291.
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